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What Does DRESS Syndrome Look Like?

DRESS Syndrome isn't pretty, but it's important to know what it looks like. Most patients develop a

maculopapular, pruritic rash that may affect the face, upper trunk, and arms and legs. The rash can begin on the trunk and move down the body and eventually develop into severe exfoliative dermatitis. Parts of the skin may become purple and bruised-looking during the course of illness. Edema (swelling) of the face and extremities will often present in the acute phase of DRESS, and jaundice (yellowing of the skin) is often seen due to liver injury.

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While these are the visual cues for DRESS, the most dangerous damage is done internally where it can't be seen. Even after patients stop the medication and the rash and edema subside, the organs can progressively get worse. We must look beneath the skin to evaluate for these signs.  

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DRESS is a progressive and varied condition. Not all symptoms will appear at once and not all patients will experience every symptom. 

DRESS Syndrome Rash

An early sign of DRESS, rashes may be itchy and painful, and may vary in presentation. The rash usually progresses through the course of illness, moving from the trunk to the extremities.

Facial Edema (Swelling)

Facial edema is a hallmark sign of DRESS that typically presents within the first few weeks of illness. Some patients will have a facial rash along with swelling, others will not. 

Skin Exfoliation:Peeling/Shedding

Skin exfoliation may occur after a rash and involve any body part. Some may have "sheets" of skin peel off at times.

Additional Images of DRESS Syndrome

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Legal: This website is for information purposes only and is not intended to diagnose or treat DRESS or any other type of disease. Every patient’s situation is unique. We are a patient advocacy organization and are not medically trained. Never disregard professional medical advice or delay seeking it because of something you’ve read on this site. In the hope of creating better awareness, we encourage you to share what you learn here with your medical team and others. If you think you may have a medical emergency, call your doctor or 911 immediately.  

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